Johns Hopkins University | Krieger School of Arts and Sciences
University News | Search JHU
The Chemistry-Biology Interface (CBI) Graduate Program
Advising Thesis Research |
Search JHU: |
CBI Program 410-516-7427 phone
|
CBI faculty • Scott Bailey - structure/function studies of genome integrity • Jürgen Bosch - anti-malarial drug discovery through X-ray crystallography • Philip Cole – chemical and biochemical approaches to signal transduction • Robert Cotter - mass spectrometry • Val Culotta - cellular transport and trafficking of heavy metals, antioxidant enzymes • David Draper – RNA stability and electrostatics, RNA-protein recognition • Ernesto Freire - structure-based thermodynamics of molecular recognition and function • David Goldberg - models of zinc and iron enzymes, mechanisms of metal-catalyzed hydrolysis and oxidation, porphyrinoid synthesis and reactivity • Marc Greenberg – chemical, biochemical, and biological studies on DNA damage and repair, design of sensors for DNA damage, radiosensitizing agents, and inhibitors of DNA repair enzymes • Blake Hill – NMR studies of protein folding, computational protein design, modeling protein dynamics using NMR spin relaxation date, and structural biology • Kenneth Karlin - bioinorganic chemistry; copper and heme biomimetic O2 and nitrogen oxide chemistry; DNA and peptide metal complex chemistry • Juliette Lecomte - determinants of protein structure and dynamics in solution; NMR spectroscopy of heme proteins • Thomas Lectka - catalytic, asymmetric methodology; synthesis of biologically active molecules including beta-lactams; synthesis of new inhibitors • Yuan Lee - glycoproteins, glycolipids, and cell-surface substances. • Jun Liu - use of small molecules as probes to elucidate mechanisms of signal transduction; angiogenesis and cell proliferation. • Roger McMacken – function of multiprotein assemblies, initiation mechanisms for DNA replication, mechanisms of molecular chaperone action • Caren Freel Meyers - drug delivery mechanisms in bacteria; development of antibiotic prodrug strategies; study of bacterial isoprenoid biosynthesis; combinatorial biosynthesis • Paul Miller – nucleic acid bioorganic chemistry • Marc Ostermeier - protein engineering, directed evolution, allostery • Gary Posner - Medicinal, Organic and Organometallic Chemistry • Justine Roth - metalloenzyme catalysis, mechanistic studies of O2 activation and protein damage by reactive oxygen species • Joel Schildbach – structural, biochemical, and functional studies of proteins involved in DNA transfer by bacterial conjugation • James Stivers – enzymology of DNA repair and topoisomerases, structure and mechanism by NMR spectroscopy, inhibitor design • Joel Tolman – biomolecular recognition, structural genomics, experimental and theoretical NMR • John Toscano - new precursors to NO and HNO, NO-releasing materials, the potential role of HNO in the treatment of heart failure • Craig Townsend – natural product chemistry, enzymology and molecular biology, fatty acid synthase inhibitors for cancer, tuberculosis and obesity • Herschel Wade - molecular switch energetics-landscapes and allosteric mechanisms, molecular recognition principles of multidrug resistance proteins • Sarah Woodson - RNA folding and catalysis; dynamics of small regulatory RNAs; mechanism of 30S ribosome assembly by time resolved footprinting • Jin Zhang - cell signaling; kinases and phosphatases; chemotaxis; live-cell imaging; fluorescent proteins and reporters • Heng Zhu - develops and applies the protein chip technology to investigate important biological questions and to help clinical research. Research focus includes networks and pathways of protein posttranslational modifications, gene transcription regulatory networks, pathogen-host interaction networks, and biomarker discovery. Research Affiliates • Ananya Majumdar - Director of the Biophysical NMR Center |
About the Program | Faculty | Admissions | Curriculum | Departments | Contact Information |
| © The Johns Hopkins University. All rights reserved. |