The Chemistry-Biology Interface (CBI) Graduate Program
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CBI faculty • Philip Cole – chemical and biochemical approaches to signal transduction • Robert Cotter - mass spectrometry • Val Culotta - cellular transport and trafficking of heavy metals, antioxidant enzymes • David Draper – RNA stability and electrostatics, RNA-protein recognition • Ernesto Freire - structure-based thermodynamics of molecular recognition and function • David Goldberg - models of zinc and iron enzymes, mechanisms of metal-catalyzed hydrolysis and oxidation, porphyrinoid synthesis and reactivity • Marc Greenberg – chemical, biochemical, and biological studies on DNA damage and repair, design of sensors for DNA damage, radiosensitizing agents, and inhibitors of DNA repair enzymes • Les Hanakahi – molecular mechanisms of DNA double stand break repair • Blake Hill – NMR studies of protein folding, computational protein design, modeling protein dynamics using NMR spin relaxation date, and structural biology • Kenneth Karlin - bioinorganic chemistry; copper and heme biomimetic O2 and nitrogen oxide chemistry; DNA and peptide metal complex chemistry • Juliette Lecomte - determinants of protein structure and dynamics in solution; NMR spectroscopy of heme proteins • Thomas Lectka - catalytic, asymmetric methodology; synthesis of biologically active molecules including beta-lactams; synthesis of new inhibitors • Yuan Lee - glycoproteins, glycolipids, and cell-surface substances. • Jun Liu - use of small molecules as probes to elucidate mechanisms of signal transduction; angiogenesis and cell proliferation. • Roger McMacken – function of multiprotein assemblies, initiation mechanisms for DNA replication, mechanisms of molecular chaperone action • Caren Freel Meyers - drug delivery mechanisms in bacteria; development of antibiotic prodrug strategies; study of bacterial isoprenoid biosynthesis; combinatorial biosynthesis • Paul Miller – nucleic acid bioorganic chemistry • Marc Ostermeier - protein engineering, directed evolution, allostery • Gary Posner - Medicinal, Organic and Organometallic Chemistry • Justine Roth - metalloenzyme catalysis, mechanistic studies of O2 activation and protein damage by reactive oxygen species • Joel Schildbach – structural, biochemical, and functional studies of proteins involved in DNA transfer by bacterial conjugation • James Stivers – enzymology of DNA repair and topoisomerases, structure and mechanism by NMR spectroscopy, inhibitor design • Joel Tolman – biomolecular recognition, structural genomics, experimental and theoretical NMR • John Toscano - new precursors to NO and HNO, NO-releasing materials, the potential role of HNO in the treatment of heart failure • Craig Townsend – natural product chemistry, enzymology and molecular biology, fatty acid synthase inhibitors for cancer, tuberculosis and obesity • Herschel Wade - molecular switch energetics-landscapes and allosteric mechanisms, molecular recognition principles of multidrug resistance proteins • Sarah Woodson - RNA folding and catalysis; dynamics of small regulatory RNAs; mechanism of 30S ribosome assembly by time resolved footprinting • Jin Zhang - cell signaling; kinases and phosphatases; chemotaxis; live-cell imaging; fluorescent proteins and reporters |